If you have a WordPress blog, I highly recommend Elliott Back’s Spam Stopgap Extreme plugin. Super simple to install, and you just stop getting comment spam, simple as that. I’m sure, eventually, that the comment spammers will get sophisticated enough to get around this method of blocking, but until then, this is my spam blocking plugin of choice.
Please note: I've moved my active blogging over to a new site, called Jason Clarke - Infinite Bass Line. I will leave this site up indefinitely, but if you're interested in my latest posts please consider visiting the new site.